Connect with us

Tech

Synex founder, once detained at the border with a 80-pound magnet, is building portable MRIs to test glucose

Back in 2019, Synex Medical founder Ben Nashman spent the night detained by US customs. Nashman tried to explain he was simply transporting materials from Buffalo to Toronto for his homemade MRI. Customs, however, took issue with the label on the package: “nuclear magnetic resonance.” 

Nashman spent hours in a bright waiting room before he finally convinced them that he was really just a run-of-the-mill 18-year-old scientist with an obsession with MRI technology. They let him take his roughly 80-pound magnet and he zoomed back to Toronto. “I got back at like 3 or 4 am and got a few hours of sleep before classes,” he said. 

Nashman, now 24, might have landed himself on a list of suspicious individuals, but he insists it was worth it: that one very long night was part of his years-long journey to build a portable MRI capable of testing glucose and other important molecules without the need to extract blood. Today, the company is one step closer to that goal, announcing a $21.8 million Series A fundraise, with investors like Accomplice, Radical Ventures, Fundomo and Khosla Ventures. It brings the company’s total haul up to over $36 million, with includes seed funding from Sam Altman. 

Right now, Synex’s prototype is the size of a toaster, although Nashman hopes to one day have it fit in your palm. It works by first using MRI to create a 3D image of the finger to find the best spot to test. It then uses something called magnetic resonance spectroscopy to send radio pulses that “excite the different molecules,” Nashman said. The machine then takes the signals from all the molecules and filters for a specific one. Synex will start with glucose testing, but will eventually track things like amino acids, lactate and ketones.  

The company introduced me to Diane Morency, a woman based in Massachusetts who has suffered from Type 2 diabetes for years. “I’ve got holes in my fingers,” she told me, adding she can no longer play her ukulele because of the pain. “It would be a godsend to not have to prick my [fingers] anymore.” 

But there’s a reason non-invasive glucose testing hasn’t been commercialized: it’s difficult to track glucose accurately without drawing blood, and it’s even harder to make the device portable or affordable. “We believed that was going to be an absolute moonshot,” said Jun Jeon, an investor at Khosla Ventures focusing on healthcare. 

Jeon has yet to try Nashman’s prototype but said that, if Nashman can deliver on his promises, then “this was a bet worth taking.” 

An obsession with longevity

Nashman was always curious about living forever. 

When he was about 16, he walked into his vet’s office armed with printed-out scientific studies. He had determined that his dog should be put on the immunosuppressive drug rapamycin, a drug controversially heralded by longevity enthusiasts. The vet had no idea what Nashman was talking about. “He was just like, ‘this is just way too experimental for me,’” Nashman recalled. 

The vet’s refusal didn’t deter him. “Later, I got my parents on it and I got on it,” he laughed. “Honestly, I think everything should be on it.” 

It was the first of several longevity self-experiments. Nashman briefly took diabetes drug arcarbos, forked over thousands for a Prenuvo full body scan, and, like so many in Silicon Valley before him, got his hands on a continuous glucose monitor. His health obsession coincided with a fascination with physics — particularly the “elegant” science behind MRIs, and how much they could reveal about the human body. 

By 17, he had ordered materials online to make a makeshift MRI in his bedroom (it was “really crap,” he said). By 18, he had held an internship working on brain imaging at the Mount Sinai Hospital in Toronto and enrolled at the University of Toronto for engineering science. “I think I have the record for most MRIs ever, probably,” he said. “I’ve probably scanned my finger honestly 1000s of times at this point.” 

He realized that MRI technology could be the ultimate longevity hack, giving him more information about his body than an Oura Ring or Whoop ever could. He first sold his dreams to Altman, whom he met in 2019, and then Peter Thiel, landing the Thiel Fellowship in 2021. 

Nashman may have Silicon Valley’s overlords on his side, but he’s still entering a very crowded space with well-capitalized competition. Startups like Know Labs and Berlin-based DiaMonTech are both making their own non-invasive products. Apple has reportedly been quietly working on a non-invasive glucose monitor, and Google too once tried to make its own glucose monitoring contact lens before pausing the project in 2018

Synex Medical faces an uphill battle from here. The company will have to undergo rigorous clinical trials to prove to the FDA that its machine can accurately isolate glucose molecules. There’s also the lingering question of whether Nashman can really get technology to a portable size. If not, “It wouldn’t be too useful,” Morency said. “It would do us no good outside of the house.” 

But let’s say Nashman nails all of that. Let’s say Synex soars through its FDA-approved trials and successfully shrinks its current metal toaster down to something that fits in your palm. It will still debut in a healthcare industry that has long struggled to make new technology affordable, according to Khosla investor Jeon. “There’s not a lot of good infrastructure and reimbursement that will allow for all patients to have access to the technology,” Jeon said. 

For Nashman, the chance for a longer life is worth dedicating his own life to. “I want to know exactly what my body needs. I want to know what my parents need,” he said. “A technology like this is just needed to usher in that age of predictive medicine.” 

source

Continue Reading
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

Tech

Anthropic created a test marketplace for agent-on-agent commerce

In a recent experiment, Anthropic created a classified marketplace where AI agents represented both buyers and sellers, striking real deals for real goods and real money.

The company admitted this test — which it called Project Deal — was only “a pilot experiment with a self-selected participant pool” of 69 Anthropic employees who were given a budget of $100 (paid out via gift cards) to buy stuff from their coworkers.

Nonetheless, Anthropic said it was “struck by how well Project Deal worked,” with 186 deals made, totaling more than $4,000 in value.

The company said it actually ran four separate marketplaces with different models — one that was “real” (where everyone was represented by the company’s most-advanced model, and with deals actually honored after the experiment) and another three for study. 

Apparently, when users are represented by more advanced models, they get “objectively better outcomes,” Anthropic said. But users didn’t seem to notice the disparity, raising the possibility of “‘agent quality’ gaps” where “people on the losing end might not realize they’re worse off.”

Also, the initial instructions given to the agents didn’t appear to affect sale likelihood or the negotiated prices.

source

Continue Reading

Tech

Nuclear startup X-energy raises $1B in data center-driven IPO

Nuclear startup X-energy raised $1 billion in its initial public offering yesterday, selling 44.3 million shares for $23 each, a hefty premium above the $16 to $19 per share it was seeking. Initially, the company had hoped to raise around $800 million.

The stock is expected to begin trading on Friday on the Nasdaq Exchange under the ticker XE.

X-energy is building small modular reactors capable of generating electricity or delivering heat to industrial processes. The company has a deal with Dow to provide heat and power to a chemical plant in Texas and another with Amazon to sell as much as 5 gigawatts of nuclear power by 2039. Amazon’s Climate Pledge Fund led X-energy’s Series C-1 round.

Nuclear startups like X-energy have been buoyed by surging demand for electricity from data centers and other parts of the economy that have been electrifying.

The company says its reactors will generate 80 megawatts of electricity. Each Xe-100 reactor is cooled by helium gas, which flows over billiard ball-sized “pebbles” that are packed with BB-sized TRISO fuel pellets. TRISO fuel, which contains a kernel of uranium wrapped in carbon and silicon, was developed years ago to be safer than existing fuel designs, though it hasn’t been widely used. X-energy says its fuel can withstand higher temperatures, helping to keep the fuel contained and reduce the potential of a meltdown.

source

Continue Reading

Tech

Marked-up Mac minis flood eBay amid shortages driven by AI

Overpriced Mac minis are flooding eBay amid shortages of the sold-out machines, which have become a favored tool for running on-device AI models like OpenClaw.

This week, reports indicated that the $599 M4 Mac mini base model with 16GB RAM and 256GB of storage is sold out on Apple’s retail website, with no options for delivery or in-store pickup. The shortages have since extended to other configurations of the base model, regardless of the amount of memory selected. This is the first time the base model has been sold out, some outlets noted. Meanwhile, models with higher storage (512GB and up) are only available to ship starting in June.

As a result, eBay has become a secondary market for these in-demand computers. On the site, various configurations of the M4 Mac mini are available for sale at higher prices than if buying direct from Apple, which is no longer an option.

Apple’s power-efficient Mac minis have become popular devices for testing and running at-home, on-device AI models, beginning with the OpenClaw craze but now extending to OpenClaw alternatives like ZeroClaw, other AI tools from Anthropic and OpenAI, Perplexity Computer, or other specialized local models. Unlike some PCs, Mac minis also run quietly and tend to be more reliable for 24/7 use, compared with laptop computers.

The shortage of the devices also comes alongside an industry-wide memory crunch and plans for a Mac mini refresh, according to Bloomberg. However, refreshes of product lines haven’t led to shortages before.

Apple did not immediately respond to a request for comment.

This perfect storm of supply chain stress and increased demand for AI-friendly machines has inflated the prices of used consumer electronics.

As of Friday morning, M4 base models with the 16GB RAM/256GB SSD configuration were selling at markups like $715-$795 for a new, “open box” model, and as high as $979 for an “excellent” refurbished version. Some “lightly used, pre-owned” Mac minis with this configuration were selling for around $700 — more than $100 more than the price of a new base model.

Image Credits:eBay (screenshot)

There was also a single listing for a $925 brand-new M4 Mac mini with the same 16GB RAM and 256GB storage; the listing warned in bright red text: “Last one.”

Image Credits:eBay (screenshot)

While you still may be able to score a reasonably priced refurb if you keep a close eye out (or if you win an eBay auction where the bid has started at a lower price point), it seems that the demand for the device is going to keep prices up until Apple’s supply chain refreshes.

And now that the Mac mini is unavailable, Apple has begun to see increased demand for the Mac Studio, too. That computer is also now sold out across several configurations.

As Ars Technica pointed out, you can still get a MacBook Pro with 128GB RAM and larger SSDs within a few weeks, and even the new and popular MacBook Neo is still shipping within two to three weeks. This suggests the real issue is consumer demand for the Mac mini itself.

When you purchase through links in our articles, we may earn a small commission. This doesn’t affect our editorial independence.

source

Continue Reading