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Athletics vs. Diamondbacks Predictions: Best Bets, Odds and Props for Monday

May 23, 2026; Phoenix, Arizona, USA; Arizona Diamondbacks second baseman Ketel Marte (4) watches after hitting a two run home run against Colorado Rockies starting pitcher Michael Lorenzen (24) during the fourth inning at Chase Field. Mandatory Credit: Anna Carrington-Imagn ImagesMay 23, 2026; Phoenix, Arizona, USA; Arizona Diamondbacks second baseman Ketel Marte (4) watches after hitting a two run home run against Colorado Rockies starting pitcher Michael Lorenzen (24) during the fourth inning at Chase Field. Mandatory Credit: Anna Carrington-Imagn Images

The Athletics (42-57) head to Chase Field in Phoenix to battle the Arizona Diamondbacks (51-48) in Game No. 100 for both teams.

The A’s were playing some good ball earlier in the season, but they’ve been in a nosedive for a while now, and the A’s currently sport a minus-114 run differential, worst among all teams in the majors. In fact, with the Kansas City Royals sitting at minus-99, the A’s are the only triple in triple digits in the category.

The A’s hit the road with a 22-27 mark on the road, and they’re just 18-24 in interleague play in 2026.

For the Diamondbacks, they’re just 12-15 in interleague play, but Arizona has a respectable 29-21 mark at home, while it took two of three games over the weekend against the St. Louis Cardinals, including wins in the past two.

While Arizona’s record against the AL leaves a lot to be desired, it will be facing LHP Jeffrey Springs (3-9, 6.08 ERA, 1.42 WHIP). That’s great news for the Diamondbacks, as they’re 15-7 against left-handed starting pitchers, the fewest losses in the majors. In fact, no other team has fewer than 10 losses vs. LHP.

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The Diamondbacks should be able to roll up some huge totals against Springs, who leads the majors with 26 homers allowed in just 97 ⅔ IP across his 19 starts. He also gets himself into a lot of trouble with 37 walks. Springs is a little better on the road, than at home, going 1-3 with a 5.19 ERA and 10 homers allowed in 43 ⅓ IP, but that’s not exactly encouraging.

Arizona counters with Canadian-born LHP Mitch Bratt (0-0, 6.00 ERA, 1.67 WHIP). He’ll be making just his third Major League start, and it will be his first showing in front of the home fans. It’s set up to be a very good spot for him to make his home debut, but with a 23-year-old pitcher who doesn’t go deep into games, there is risk.

However, the A’s are 12-22 vs. LHP this season, so the rookie could look a lot better than he actually is.

We’re going to take the DIAMONDBACKS -1.5 (+124) on the run line at plus-money, although if you’re a bit on the conservative side, backing the Snakes (-163) as moderate favorites is perfectly OK.

In addition, we’re going to go OVER 9 (-122), as Springs should give up his fair share of runs, and Bratt might also give up a few. If Springs gets knocked around, there isn’t a lot of help behind him. The A’s rank dead-last in the majors in bullpen ERA (5.51). The Diamondbacks are middle of the road in bullpen ERA (3.95).

And, for an extra bonus, since Springs is so giving, let’s take KETEL MARTE – ANYTIME HOME RUN (+326) for the chance to go more than 3X. Marte is slashing .299/.346/.588 against lefties with seven homers in just 97 at-bats. Let’s roll it up!

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