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What the Polaris Dawn mission could reveal about human health in space

SpaceX’s Polaris Dawn mission, in which billionaire Jared Isaacman and three other crew members traveled to space in a Crew Dragon, has made headlines for including the first-ever private spacewalk. While the flight has been hailed as historic for that reason, Isaaman has said that the trip is not merely for fun but is making contributions to science as well. 

The research in the Polaris program, planned to be three flights, is particularly focused on human health and the effects of spaceflight on the body. The current mission will be studied by Baylor College of Medicine, with the astronauts giving blood and going through extensive biomedical testing both before and after the flight.

But what sets the Polaris Dawn mission apart is its altitude, 870 miles above the Earth’s surface to be exact. That’s far higher than the typical altitude of the International Space Station, at around 250 miles, and makes Polaris Dawn the farthest humans have been from Earth since the Apollo missions. 

The effects of spaceflight on the body

That altitude took the craft through Earth’s inner Van Allen belt, a region of charged particles that protect the planet from dangerous radiation. The crew members are fitted with sensors to measure their cumulative radiation exposure over the mission, and the spacecraft interior is fitted with a sensor to detect the different types of radiation in the environment.

“It’s an opportunity to see what kind of [radiation] exposure that we get as they get further and further away from the surface of the Earth,” explained Baylor’s Translational Research Institute for Space Health deputy director Jimmy Wu. “That’s something that we don’t have a whole lot of data on, because we’ve been limited to the number of humans that have been that far. So that’s critically important to understand.”

This still image taken from a SpaceX and Polaris broadcast on September 15th shows the manned Polaris Dawn mission’s “Dragon” capsule splashing down off the coast of Dry Tortugas, Florida, completing the first human spaceflight mission by non-government astronauts of the Polaris Program. 
Photo by Polaris Program / AFP via Getty Images

Short and sweet

From a health researcher’s point of view, more data is always welcome, whether it’s from a space agency mission or a private one. Though the Polaris Dawn mission is much shorter than a typical astronaut rotation on the International Space Station, at five days rather than six months or more, that still provides an opportunity for a different type of research.

If you want to look into the long-term effects of spaceflight on health, such as loss of muscle and bone mass, then you need a longer-duration mission. But with certain effects of spaceflight, the body adjusts to a baseline within a few days or a few hours, and these are ideal research topics for short missions.

Astronauts can experience space motion sickness when they enter or leave a microgravity environment, and it’s not yet known why some people suffer from this more than others, especially in the first few days of spaceflight.

“It’s an opportunity to see what kind of [radiation] exposure that we get as they get further and further away from the surface of the Earth”

While being space sick seems like more of an annoyance than a major problem, Wu points out that being impaired immediately following a launch or landing event could be a big issue. 

“You go to the Moon. There’s no welcoming committee to take care of you when you land,” he said. “What would happen if there was some sort of mishap during landing, and you had to get out? Are you going to be able to functionally do that if you’ve lost your orientation and sense of up and down?”

Another key area of health research is the relationship between different factors in spaceflight and how they affect each other. It’s not just about understanding the effects of either microgravity or radiation exposure or isolation and confinement — it’s about understanding the cumulative stresses on the body that going to space entails.

US mission Commander Jared Isaacman (L) and US mission pilot Scott Poteet (R) in the manned Polaris Dawn mission’s “Dragon” capsule after it splashed down.
Photo by Polaris Program / AFP via Getty Images

The breadth of humanity

While proponents of space tourism argue that it is increasing access to space, even democratizing space access, that can be hard to swallow when the only people going to space are billionaires like Isaacman and their friends.

However, it’s also true that the astronauts who currently fly on space agency missions are not representative of the general public. Some of that is necessary — it’s only sensible to select astronauts who are healthy enough to withstand the physical challenges of spaceflight — and some of it is a legacy of racism, sexism, and who is perceived to be worthy of becoming an astronaut.

Efforts to diversify international astronaut corps are underway, and the European Space Agency recently selected its first disabled astronaut for training. But still, the people flying on space agency missions are a very limited slice of the human population, and so the only data we have on spaceflight health outcomes are related to this small group. 

“I think it’s really important to understand the breadth of humanity so that we can understand the full spectrum of how humanity would perform in space flight, not just the folks who were our early pioneers,” Wu said.

Though commercial astronauts to date have been primarily, although not exclusively, white men, they have represented a wider range of ages and backgrounds than is typical for professional astronauts. And future commercial missions could help widen the pool of data on human health in space. The Polaris Dawn crew consists of an equal balance of men and women, for example, allowing for comparisons between genders.

TRISH is setting up a database that will collect biomedical data from both Polaris Dawn and future commercial space missions. The aim is to collect data from a wider range of people, not just highly trained, young astronauts with no medical conditions, to see how people with preexisting conditions like diabetes or cardiovascular disease fare on space missions.

“We have got to start collecting that data because we don’t know how these [conditions] would behave in space,” Wu explained.

SpaceX’s Polaris Dawn Falcon 9 rocket blasts off from Launch Complex 39A of NASA’s Kennedy Space Center on September 10th.
Photo by Joe Raedle / Getty Images

An impact on Earth

One experiment on the Polaris Dawn mission that could have an outsize impact is something that seems, on the face of it, quite simple: testing out a miniaturized ultrasound scanner that the crew can use to scan themselves and collect medical data. The researchers are looking at not only the performance of the device but also the best way to train the crew on its use.

“We have got to start collecting that data because we don’t know how these [conditions] would behave in space”

Although adapting hardware for space comes with its own challenges, the preparation for using a handheld medical scanner, particularly for people who aren’t trained medical professionals, is about education and procedure.

“There’s a line of research around that: how do we provide pre-flight training before they go on the mission, so they can at least understand some fundamentals?” Wu explained. “And then, can we provide just-in-time training? So as they’re preparing for the actual activity, can you give them a refresher?”

Finding the best way to teach nonmedical professionals to use diagnostic devices, and making those devices as small and robust as possible, turns out to not only be useful in space. It could also be invaluable here on Earth, such as in rural settings or a region where people don’t have access to doctors.

“We talk about the concepts of health equity and being able to serve underserved low resource environments,” Wu said. “If you can keep someone healthy in the remoteness of space, you should be able to do that anywhere on Earth.” 

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Trump Says US Banks Can’t Do Business in Canada. It’s Not That Simple.

Hours after imposing steep tariffs on Canada, President Trump raised an issue that even the American lenders whose cause he’s championing find perplexing: the access, or lack thereof, of U.S. banks to the Canadian market.

On Tuesday, Mr. Trump wrote in a post on Truth Social, “Canada doesn’t allow American Banks to do business in Canada, but their banks flood the American Market.” He added sarcastically, “Oh, that seems fair to me, doesn’t it?”

While this issue doesn’t often come up in conversations with prominent American bank executives, it appears to be increasingly on the president’s mind.

Mr. Trump mentioned the Canada banking issue early last month as part of a broader criticism against what he views as the unequal economic balance between the United States and its northern neighbor. Writing on Truth Social, Mr. Trump said Canada “doesn’t even allow U.S. Banks to open or do business.”

Here is the actual state of play for U.S. banks in Canada:

Canada’s banking sector is dominated by the “Big Six,” the half-dozen institutions including the Royal Bank of Canada and TD Bank. They are permitted to take deposits, extend mortgages and advise corporate clients — all the core activities for banks. And Canadian customers disproportionately still prefer to do their banking in person, as opposed to online, meaning it would require a major physical presence for any entrant to attempt to enter the market.

Additionally, U.S. banks are restricted in what they can do in Canada.

Foreign banks, including American ones, must either work with a Canadian middleman, establish a Canadian subsidiary or receive special government permission to do business. Unless they agree to follow Canada’s stringent banking rules that include holding a hefty sum of cash-like assets in reserve at all times, they cannot operate retail branches that take deposits under around $100,000.

Given how dominant Canada’s homegrown banks are, any international bank that tries to compete faces “an additional regulatory burden for what would begin as a small prize,” said James R. Thompson, associate professor of finance at the University of Waterloo.

The upshot is that U.S. banks have minimal operations in Canada. The largest American lender, JPMorgan Chase, says it has roughly 600 employees in Canada, out of more than 300,000 worldwide. Many international banks limit themselves to areas that don’t involve lending, such as offering investment advice to wealthy Canadians or local companies.

So Mr. Trump is incorrect in asserting that American banks cannot do any business in Canada, but it is true that they are hamstrung in their activities.

While there are more than 4,000 banks in the United States, Canada has just a few dozen, and more than three-quarters of deposits are held by the Big Six.

For decades, Canadian political leaders have crowed about that restrictive financial regulatory model. They argue that fending off foreign entrants in the country’s mortgage market helped the country largely avoid the 2008 collapse south of its border.

In light of Mr. Trump’s criticism, Maggie Cheung, a spokeswoman for the Canadian Bankers Association, was quick to point out on Tuesday that foreign banks were an integral part of the banking landscape. She said 16 U.S. banks were operating to some degree in Canada, with a cumulative of nearly $79 billion in assets — a statistic that the nation’s prime minister, Justin Trudeau, also cited on Tuesday.

“American banks are alive and well and prospering in Canada,” Mr. Trudeau said.

But in relative terms, their successes are small. U.S. bank assets represent 1 to 2 percent of the $6.5 trillion held by banks operating in Canada writ large.

“The major impediment faced by U.S. banks,” said Laurence Booth, professor of finance at the University of Toronto, “is simply they can’t compete with the Canadian banks as they don’t have the scale, while they can’t take any of them over as there are restrictions on foreign ownership.”

International banks — including Canadian ones — are largely free to establish U.S. arms. The United States is a more attractive target for international banks than Canada, both because it is a hub for world finance and because its market permits more exotic, higher-profit lending activities like 30-year mortgages. (The most common mortgage in Canada carries a five-year term.)

The largest Canadian bank in America, TD Bank, operates more than 1,000 U.S. branches through a Delaware subsidiary. That size puts it in line with well-known regional lenders like Citizens and Fifth Third.

The Canadian Bankers Association said the six largest Canadian lenders held less than 3.5 percent of U.S. bank assets.

Big U.S. banks had plenty of hopes that Mr. Trump would decrease regulations, encourage merger activity and slash taxes. Expanding their presence in Canada was not on the list.

A U.S. banking industry trade group, the Bank Policy Institute, said Tuesday that it had released no statements on the matter, and no bank chief executive has taken up the rallying cry.

More pressing for the global banking industry are Mr. Trump’s tariffs, which have helped push the industry’s stocks down 8 percent over the past month, according to the KBW Nasdaq Bank Index.

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Trump’s New Tariffs Could Strain Collection of Customs Fees

The sweeping tariffs on Canadian, Mexican and Chinese products that President Trump imposed on Tuesday could strain the system that collects import duties and the government agencies that enforce those fees, trade and legal experts said.

Collecting import duties is usually a routine task, but the new tariffs are being imposed on Mexican and Canadian goods, many of which have been imported into the United States duty-free for many years. Adding to the challenge is the sheer volume of goods subject to the new tariffs — U.S. imports from China, Mexico and Canada totaled over $1.3 trillion last year, or about two-fifths of all imports.

The tariffs apply a 25 percent duty on goods from Mexico and Canada and an additional 10 percent on imports from China.

Importers typically employ customs brokers to calculate and pay tariffs to the government agency that collects them, U.S. Customs and Border Protection.

Adam Lewis, a co-founder and the president of Clearit, a customs broker, said that it would not be hard to tweak software to collect the new tariffs, but that a crucial part of the tariffs payment system might need significant adjustments. Importers must buy a “customs bond,” a type of insurance that guarantees the duties will be paid. Mr. Lewis said some customers might have to increase the size of their bonds to cover the extra tariff payments.

“Many of their products were coming in duty-free, and all of a sudden there’s going to be a 25 percent increase,” he said. “It’s quite large.”

In addition, policing importers for tariff evasion will now become a much bigger task for Customs and Border Protection and the Department of Justice. Some importers may try to avoid tariffs by understating the cost of goods in customs declarations or by falsely claiming they were imported from countries not subject to tariffs.

“The greater the breadth and severity of these new tariffs, the greater the likelihood that at least some potential importers may want to misrepresent the value or the origin of their goods,” said Kirti Vaidya Reddy, a former federal prosecutor who is now a partner at the law firm Quarles.

If the government finds that an importer has not paid duties, customs officials are likely to demand that the importer pay what is owed and a penalty that can double or even triple the amount due.

In a statement, a customs agency spokeswoman said: “The dynamic nature of our mission, along with evolving threats and challenges, requires C.B.P. to remain flexible and adapt quickly while ensuring seamless operations and mission resilience. These tariffs will help maintain America’s global competitiveness and protect American industries from unfair trade practices.”

Some evasion cases have become the subject of criminal prosecutions. Last year, a Miami importer pleaded guilty to participating in an import scheme involving Chinese truck tires that the Justice Department said had cost the United States more than $1.9 million in forgone tariff revenue.

But stepping up enforcement efforts is likely to require that the Justice Department devote significantly more staff to pursuing tariff evasion cases, which, lawyers said, can take time to build.

“The Department of Justice has the personnel and infrastructure to do it, but these cases are complex, transnational and document-heavy,” said Artie McConnell, a former federal prosecutor who is a partner at the law firm BakerHostetler. “You can’t rush it, and prosecutions likely won’t come quickly.”

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China Retaliates Against Trump, Imposing Tariffs and Blacklisting U.S. Companies

Minutes after President Trump’s latest tariffs took effect, the Chinese government said on Tuesday that it was imposing its own broad tariffs on food imported from the United States and would essentially halt sales to 15 American companies.

China’s Ministry of Finance put tariffs of 15 percent on imports of American chicken, wheat, corn and cotton and 10 percent tariffs on other foods, ranging from soybeans to dairy products. In addition, the Ministry of Commerce said 15 U.S. companies would no longer be allowed to buy products from China except with special permission, including Skydio, which is the largest American maker of drones and a supplier to the U.S. military and emergency services.

Lou Qinjian, a spokesman for China’s National People’s Congress, chastised the United States for violating the World Trade Organization’s free trade rules. “By imposing unilateral tariffs, the U.S. has violated W.T.O. rules and disrupted the security and stability of the global industrial and supply chains,” he said.

President Trump has contended his tariffs are essential to stopping the flow into the United States of fentanyl, a synthetic opioid that has caused hundreds of thousands of deaths through overdoses.

But the U.S. imposition of tariffs “will deal a heavy blow to counternarcotics dialogue and cooperation,” Lin Jian, a spokesman for China’s Ministry of Foreign Affairs, said at a news briefing.

Mr. Trump has now tagged almost all goods from China with an extra 20 percent in tariffs since taking office in January. He announced 10 percent tariffs on Feb. 4 and another round on Tuesday. Mr. Trump also moved ahead on 25 percent tariffs on Mexico and Canada on Tuesday, after a monthlong delay.

China had responded to the February tariffs by immediately announcing that it would start collecting, six days later, additional tariffs on liquefied natural gas, coal and farm machinery from the United States. But those tariffs combined hit only about a tenth of American exports to China, making them much narrower than Mr. Trump’s comprehensive tariffs.

China’s action on Tuesday was much broader. China is the top overseas market for American farmers, wielding considerable influence over prices and demand in the commodities markets of the Midwest.

By targeting imports of food, Beijing repeated its response to tariffs that Mr. Trump imposed during his first term. China put tariffs on American soybeans in 2018 and shifted much of its purchasing to Brazil.

But the strategy backfired then: Mr. Trump responded by placing more tariffs on Chinese goods. Because China sells much more to the United States than it buys, it quickly ran out of American goods to impose tariffs on. And American farmers had some success in finding other markets for their crops.

China’s tariffs in 2018 also had less of a political impact in the United States than Beijing’s leaders had hoped. In 2018 Senate elections in three of the top soybean-exporting states, voters gave little evidence they held the Chinese action against Mr. Trump or the Republican Party. All three states saw Democratic senators replaced with Republicans that year, as social issues proved more compelling for many voters than trade disputes.

Yet China has potential trade weapons that go beyond tariffs on food. In early February, Beijing implemented restrictions on exports to the United States of certain critical minerals, which are used in the production of some semiconductors and other technology products.

Blocking key materials from reaching the United States, a tactic known as supply chain warfare, carries considerable risks for China. Beijing is struggling to attract foreign investment. China’s leaders have also stated that attempting to bolster the country’s domestic economy, weighed down by the fallout of a devastating real estate slowdown, is a priority.

Beijing could make it even harder for American companies to do business in China, but that could also hurt foreign investment. In addition to effectively preventing 15 companies from buying Chinese goods, China’s Ministry of Commerce added another 10 American companies on Tuesday to what it calls an “unreliable entities list,” preventing them from doing any business in China.

Many of the companies that China penalized on Tuesday are military contractors. But the Ministry of Commerce also blocked imports from the biotech firm Illumina. It accused Illumina, which is based in San Diego, of violating market transaction rules and discriminating against Chinese companies.

Chinese market regulators said in early February, after Mr. Trump imposed tariffs, that they had launched an antimonopoly investigation into Google. Google has been blocked from China’s internet for more than a decade, but the move could disrupt the company’s dealings with Chinese companies.

Mr. Lou, the National People’s Congress spokesman, signaled his country’s emerging strategy in dealing with Mr. Trump’s tariffs by calling for closer trade relations with Europe.

“China and Europe can complement each other’s strengths and achieve mutual benefit in many areas of cooperation,” he said at a news conference ahead of the opening on Wednesday of the annual weeklong session of China’s legislature.

But Europe has its own trade disputes with China, notably over electric vehicles. European politicians and business leaders have voiced concern about how to cope with an expected further flood of exports this year from China, which has embarked on a far-reaching factory construction program.

China’s rapid rise since 2000 to global pre-eminence in manufacturing, with a third of the world’s output, has come to a considerable extent at the expense of the American share of global industrial production, according to United Nations data. European nations have been wary of closing factories and relying on low-cost imports from China.

Mr. Trump has moved much faster on China tariffs during his second term than he did in his first. In 2018 and 2019, he imposed tariffs of up to 25 percent, in stages, on imports worth about $300 billion a year. He then concluded a trade agreement with China in January 2020, leaving in place 25 percent tariffs on many industrial goods while cutting 15 percent tariffs on some consumer products to 7.5 percent and canceling a few other tariffs.

By contrast, Mr. Trump has now imposed 20 percent tariffs on all goods that the United States imports from China, worth about $440 billion a year. That includes some products, like smartphones, that he omitted during his first term.

Mr. Trump’s actions this year have raised average tariffs on the affected Chinese imports to 39 percent — compared with just 3 percent before he took office in 2017. Apart from China, Canada and Mexico, the United States imposes tariffs averaging about 3 percent on most trading partners.

China’s average tariffs on goods from most of the world are twice as high, and much higher on imports from the United States.

In Mr. Trump’s first term, the Chinese government reduced taxes that it charges the country’s exporters. That gave them room to cut prices and offset at least part of the tariffs for their customers, which include many small American businesses as well as big retailers like Walmart, Amazon and Home Depot.

As another way around tariffs, some Chinese exporters shifted the final assembly of their products to countries like Vietnam, Thailand or Mexico, while keeping the production of core components in China. Mr. Trump is now trying to stop some of the trade through Mexico, which critics of Chinese exports see as a backdoor into the U.S. market.

Many Chinese exporters resorted to using the so-called de minimis exception to tariffs: dividing shipments into many packages, each with a value of less than $800. Each shipment is then exempt from tariffs and customs processing fees and mostly omitted from customs inspections and American imports data.

At least $1 of every $6 worth of American imports from China is now arriving through these de minimis shipments.

In early February, Mr. Trump issued an order briefly halting the de minimis tariff exemption for goods from China, Mexico and Canada. After packages quickly accumulated at American airports, he delayed the order for shipments from China until procedures could be developed to handle them, and postponed for a month his order for de minimis imports from Canada and Mexico. On Sunday, he again delayed action on those imports from Canada and Mexico.

Wu Xinbo, dean of the Institute of International Studies at Fudan University in Shanghai, said that by retaliating now, “China sends a strong signal to the Trump administration that a unilateral tariff doesn’t work — you have to sit down to talk to us and to negotiate with us.”

Alexandra Stevenson contributed reporting from Beijing, and Chris Buckley and Amy Chang Chien from Taipei. Li You contributed research.

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